Genetic basis of human circadian rhythm disorders
نویسندگان
چکیده
منابع مشابه
Circadian rhythm sleep disorders.
Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle. Delayed sleep phase (typical in adolescents) and advanced sleep phase (frequent in the elderly), situations in which the sleep period is displaced to a later or earlier time, respectively, are the two most prevalent circadian rhythm sleep d...
متن کاملCircadian Rhythm Sleep Disorders
Though the theories on the reasons why humans need to sleep vary, there is no disagreement that sleep is essential to our wellbeing and survival. External and internal physiological parameters dictate our own individual body “clocks,” or circadian rhythms. Typically, this clock runs very close to a 24-hour cycle of sleep and wakefulness. However, for some individuals, this clock can be slightly...
متن کاملA molecular perspective of human circadian rhythm disorders.
A large number of physiological variables display 24-h or circadian rhythms. Genes dedicated to the generation and regulation of physiological circadian rhythms have now been identified in several species, including humans. These clock genes are involved in transcriptional regulatory feedback loops. The mutation of these genes in animals leads to abnormal rhythms or even to arrhythmicity in con...
متن کاملDiagnosis of circadian rhythm sleep disorders.
Insomnia and excessive sleepiness are common in the investigation of sleep-disordered breathing. Circadian rhythm sleep disorders are perhaps the most often overlooked conditions in the differential diagnosis of these symptoms. Circadian rhythm sleep disorders manifest as misalignment between the sleep period and the physical/social 24-h environmental cycle. The two most prevalent circadian rhy...
متن کاملDrug treatment for circadian rhythm sleep disorders
Medication with drugs that are active in the brain, and therein have an effect on the suprachiasmatic nuclei of the anterior hypothalamus or areas of the posterior thalamus involved in control of sleep and wakefulness, can have either therapeutic or adverse effects on individuals with circadian rhythm sleep disorder. Currently, with a high degree of clinical certainty, there is no generally acc...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2013
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2012.07.012